Amino Tadalafil is a synthetic small-molecule compound structurally classified within phosphodiesterase inhibitor frameworks. It is characterized by its heterocyclic core and functional groups that enable interaction with enzymatic binding sites involved in cyclic nucleotide regulation.
In research settings, amino tadalafil is examined for its role in modulating phosphodiesterase type 5 (PDE5) enzyme activity. PDE5 is responsible for the hydrolysis of cyclic guanosine monophosphate (cGMP), a signaling molecule involved in intracellular second messenger pathways.
Mechanism of Action
Amino Tadalafil inside the tadalafil peptide is studied for its interaction with phosphodiesterase type 5 (PDE5), an enzyme that catalyzes the breakdown of cyclic guanosine monophosphate (cGMP).
By binding to the catalytic site of PDE5, the compound inhibits the enzymatic hydrolysis of cGMP. This results in sustained intracellular concentrations of cGMP, which plays a role in signaling pathways associated with smooth muscle regulation and vascular tone at the cellular level.
The compound’s molecular structure enables selective interaction with PDE5 over other phosphodiesterase isoforms, making it relevant in studies focused on enzyme selectivity, binding affinity, and signal transduction mechanisms.
Chemical Properties of Amino Tadalafil
| Property | Value |
| Molecular Formula | C21H18N4O4 |
| Synonyms | Aminotadalafil |
| IUPAC Name | (2R,8R)-6-amino-2-(1,3-benzodioxol-5-yl)-3,6,17-triazatetracyclo[8.7.0.03,8.011,16]heptadeca-1(10),11,13,15-tetraene-4,7-dione |
| Molecular Weight | 390.4 g/mol |
| CAS Number | 385769-84-6 |
| PubChem CID | 10178467 |
Research Applications of Tadalafil
PDE5 Enzyme Inhibition Studies
Amino Tadalafil is widely utilized in laboratory research to investigate phosphodiesterase type 5 (PDE5) inhibition. It serves as a model compound for analyzing enzyme kinetics, catalytic site binding, and inhibition constants under controlled experimental conditions.
cGMP Signaling Pathway Analysis
This compound is used in studies examining cyclic guanosine monophosphate (cGMP)-mediated signaling pathways. Research focuses on intracellular cGMP accumulation, downstream signaling cascades, and modulation of second messenger systems.
Enzyme Selectivity and Binding Affinity
Amino Tadalafil is applied in comparative studies assessing selectivity across phosphodiesterase isoforms. These investigations evaluate molecular interactions, structural compatibility, and binding affinity within enzyme active sites.
Structure-Activity Relationship (SAR) Studies
The compound is also utilized in structure-activity relationship (SAR) research to examine how molecular modifications influence enzyme interaction and inhibitory activity. This includes analysis of functional groups, stereochemistry, and binding efficiency.
Why Choose Behemoth Labz to Buy Amino Tadalafil for Research
Behemoth Labz provides research-grade Amino Tadalafil for sale manufactured under controlled laboratory conditions with strict quality assurance protocols. Each batch undergoes analytical verification to ensure consistency in molecular composition and purity.
Comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility in experimental settings. BehemothLabz maintains a compliance-focused approach, supplying compounds intended strictly for laboratory-based investigation and analytical research
Disclaimer
Amino Tadalafil is intended strictly for laboratory research and analytical purposes only. It is not intended for use in diagnostic procedures, therapeutic applications, or in vivo studies of any kind.
Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes. This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines.
Improper handling or use outside of controlled research settings is strictly prohibited.
References
- Sabra, M. S., Sayed, A. E. H., Idriss, S. K. A., & Soliman, H. A. M. (2024). Single and combined toxicity of tadalafil (Cilais) and microplastic in Tilapia fish (Oreochromis niloticus). Scientific reports, 14(1), 14576. https://doi.org/10.1038/s41598-024-64282-3
- Sadek, A. A., Sabra, M. S., Ali, M. F., Abdelhamid, H. N., & Hussein, K. (2025). Potential of tadalafil and tadalafil-cellulose nanocomposite in preventing postsurgical abdominal adhesions in a rat cecal abrasion model. Scientific reports, 15(1), 31210. https://doi.org/10.1038/s41598-025-14894-0
