Product Details: DNSP-11
DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is an 11–amino acid peptide derived from the proregion of glial cell line-derived neurotrophic factor (GDNF). It was identified in studies investigating biologically active fragments generated from the GDNF precursor protein and their effects in dopaminergic neuron models. [1][2]
GDNF is a neurotrophic factor known for its role in the survival and maintenance of dopaminergic neurons through receptor-mediated signaling pathways. The precursor form of GDNF undergoes processing that produces distinct peptide segments, which are studied to determine whether they retain biological activity independent of the mature protein. [2][3]
Mechanism of Action
Experimental studies indicate that DNSP-11 exhibits biological activity in dopaminergic neuron models that differs from full-length GDNF. The observed effects do not fully align with classical GDNF receptor signaling, indicating the potential involvement of alternative or intracellular-associated mechanisms. [1][3]
In vitro findings show that DNSP-11 can influence cellular processes associated with neuronal maintenance under stress conditions. These observations support its use as a research tool for investigating peptide-mediated signaling pathways in dopaminergic systems. [1]
Properties of DNSP-11:
- Molecular Formula: C₅₀H₈₁N₁₅O₁₈·xC₂HF₃O₂ (TFA salt)
- Molecular Weight: 1180.27 g/mol (C₅₀H₈₁N₁₅O₁₈)
- CAS Number: N/A
- PubChem CID: 25168985 for DNSP-11
- Synonyms: Dopamine Neuron Stimulating Peptide-11, GDNF Propeptide Fragment
Research Applications/Benefits DNSP-11
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Dopaminergic Neuron Function Studies
DNSP-11 is used in experimental models to investigate signaling processes in dopaminergic neurons. These neurons are widely studied due to their role in neurological conditions characterized by dopamine system dysfunction. [1][4]
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Neurodegeneration and Oxidative Stress Models
Dopaminergic neurons are particularly sensitive to oxidative stress, which contributes to neurodegenerative processes. DNSP-11 is applied in laboratory models to examine cellular responses under these conditions and to explore peptide-associated effects in stressed neuronal systems. [4][5]
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Intracellular Peptide Signaling Research
DNSP-11 provides a model for studying peptide fragments derived from neurotrophic factors and their potential activity beyond classical receptor-mediated pathways. This supports investigation into alternative signaling mechanisms within neuronal cells. [1][3]
Why Choose BehemothLabz for DNSP-11?
Choose BehemothLabz, choose quality! We are among the few online sellers that believe in the integrity and purity of products. Our DNSP-11 is designed to meet the industrial criteria and the needs of researchers.Before launching our products, we test them through an independent laboratory to check their purity and ingredients. This procedure maximizes the accuracy and findings of your research experiments.
Additionally, we deliver nationwide and internationally. We use a secure payment system that safeguards your personal information and prevents unauthorized third-party access.
So, purchase DNSP-11 now and experience quality and purity for your research.
Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments.
References
- Bradley, L. H., Fuqua, J., Richardson, A., et al. (2010). Dopamine neuron stimulating actions of a GDNF propeptide. PLoS ONE, 5(3), e9752.
- Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S., & Collins, F. (1993). GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science.
- Airaksinen, M. S., & Saarma, M. (2002). The GDNF family: signalling, biological functions and therapeutic value. Nature Reviews Neuroscience.
- Dauer, W., & Przedborski, S. (2003). Parkinson’s disease: mechanisms and models. Neuron.
- Gandhi, S., & Abramov, A. Y. (2012). Mechanism of oxidative stress in neurodegeneration. Oxidative Medicine and Cellular Longevity.
