Product Details – Tamoxifen
Tamoxifen citrate is a nonsteroidal selective estrogen receptor modulator (SERM) widely utilized in investigational research. It is structurally classified as a triphenylethylene derivative and is frequently employed in experimental models to study estrogen receptor signaling pathways.
Mechanism of Action
Tamoxifen functions as a competitive ligand of the estrogen receptor (ER), binding primarily to ERα and ERβ isoforms. Upon binding, it induces conformational changes in the receptor that alter coactivator and corepressor recruitment.
In experimental models, this results in modulation of estrogen-responsive gene transcription through interaction with estrogen response elements (EREs) in DNA. The compound exhibits tissue-selective receptor modulation due to differential expression of transcriptional cofactors in various cellular systems.
Properties
- Molecular Formula: C26H29NO
- Molecular Weight: 371.52 g/mol
- CAS Number: 10540-29-1
- PubChem CID: 2733526
- Synonyms: ICI-46474, Nolvadex, Soltamox, Genox, Tamoxen, Istubal
Research Applications
Tamoxifen is extensively utilized in investigational research for the study of estrogen receptor signaling and endocrine pathway modulation.
Common applications in preclinical and experimental models include:
- Analysis of estrogen receptor binding dynamics and ligand selectivity
- Investigation of transcriptional regulation mediated by nuclear hormone receptors
- Use in inducible gene expression systems (e.g., Cre-lox recombination models activated by tamoxifen-responsive constructs)
- Evaluation of selective receptor modulation in cellular and molecular research systems
Its role as a reference compound in in vitro studies makes it valuable for comparative analysis of other SERMs and estrogen receptor ligands.
Why Choose BehemothLabz to Buy Tamoxifen
Choose BehemothLabz for research-focused quality and consistency. Our Tamoxifen is manufactured to meet rigorous standards suitable for laboratory and experimental use.
Each batch undergoes third-party testing to verify purity, composition, and consistency. This ensures that researchers receive a product aligned with strict analytical requirements.
We offer secure ordering systems and reliable shipping options for both domestic and international customers. Our processes are designed to maintain confidentiality and protect customer data at every stage.
With BehemothLabz, you are selecting a product developed to support precision and reliability in research environments.
Disclaimer: This information is for educational purposes. We do not allow the human consumption of our products. All our products are sold for laboratory and research experiments.
References:
- Memisoglu-Bilensoy, E., Vural, I., Bochot, A., Renoir, J. M., Duchene, D., & Hıncal, A. A. (2005). Tamoxifen citrate loaded amphiphilic β-cyclodextrin nanoparticles: In vitro characterization and cytotoxicity. Journal of Controlled Release, 104(3), 489–496. https://doi.org/10.1016/j.jconrel.2005.03.006
- TrGroup, E. B. C., & Klijn, J. (1998). Tamoxifen for early breast cancer: an overview of the randomised trials. The Lancet, 351(9114), 1451–1467. https://doi.org/10.1016/s0140-6736(97)11423-4
