Enclomiphene citrate liquid is a synthetic nonsteroidal compound classified as a selective estrogen receptor modulator (SERM). It is the trans-isomer of clomiphene and is studied in biochemical research for its selective interaction with estrogen receptor subtypes (ERα and ERβ).
This compound is employed in laboratory studies examining receptor-ligand binding dynamics, modulation of endocrine signaling, and feedback regulation within hypothalamic–pituitary-associated pathways in controlled experimental environments.
Mechanism of Action
Enclomiphene citrate functions as a ligand for estrogen receptors, where it exhibits tissue-selective antagonistic and partial agonistic activity depending on receptor context and co-regulator presence.
At the molecular level, enclomiphene binds to estrogen receptors (ERα/ERβ), inducing conformational changes that alter receptor-coactivator and corepressor recruitment. This modulation influences transcriptional activity associated with estrogen-responsive elements (EREs) in DNA.
In hypothalamic–pituitary signaling models, receptor antagonism disrupts estrogen-mediated negative feedback loops, resulting in altered gonadotropin-releasing signaling cascades and downstream endocrine pathway activation in vitro.
Additionally, enclomiphene liquid is studied for its indirect influence on enzymatic pathways involved in steroidal signaling networks, including interactions affecting aromatase-associated biochemical processes, though these mechanisms remain under investigation in controlled research settings.
Chemical Properties of Enclomiphene Citrate
| Property | Value |
| Chemical Formula | C26H28ClNO · C6H8O7 |
| Molecular Weight | 598.08 g/mol |
| CAS Number | 7599-79-3 |
| Synonyms | Enclomiphene citrate, Enclomiphene |
| IUPAC Name | 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-ethanamine 2-hydroxypropane-1,2,3-tricarboxylate |
Research Applications
Estrogen Receptor Binding Studies
Enclomiphene citrate is used in laboratory settings to evaluate ligand binding affinity and selectivity toward estrogen receptor subtypes (ERα and ERβ). Studies focus on receptor occupancy, conformational changes, and ligand-receptor complex stability.
Transcriptional Regulation Analysis
The compound is applied in research examining estrogen receptor-mediated gene expression. Investigations include modulation of estrogen response elements (EREs), transcription factor recruitment, and downstream signaling effects.
Endocrine Signaling Pathway Research
Enclomiphene is utilized in studies analyzing feedback regulation within hypothalamic–pituitary-associated signaling systems. Research focuses on pathway modulation, signal amplification, and regulatory network interactions in vitro.
Structure–Activity Relationship (SAR) Studies
The compound is relevant in SAR investigations to assess how stereochemistry and structural variations influence receptor binding, signaling selectivity, and pharmacological behavior.
Why Choose BehemothLabz to Buy Enclomiphene Citrate for Research
Behemoth Labz provides Enclomiphene Citrate Liquid for sale that is manufactured under controlled laboratory conditions with strict quality assurance protocols. Each batch undergoes analytical verification to ensure consistency in molecular composition and purity.
Comprehensive documentation, including laboratory testing reports and sourcing transparency, supports reproducibility in experimental settings. BehemothLabz maintains a compliance-focused approach, supplying compounds intended strictly for laboratory-based investigation and analytical research
Disclaimer
Enclomiphene Citrate is intended strictly for laboratory research and analytical purposes only. It is not intended for use in diagnostic procedures, therapeutic applications, or in vivo studies of any kind.
Any references to biochemical pathways, receptor interactions, or enzymatic processes are provided solely for informational and research-context purposes. This compound must be handled exclusively by qualified professionals in controlled laboratory environments in accordance with applicable regulations and safety guidelines.
Improper handling or use outside of controlled research settings is strictly prohibited.
References
- Wiehle, R., Cunningham, G. R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G. K., Rosner, M., Dwyer, A., & Podolski, J. (2013). Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU international, 112(8), 1188–1200. Advance online publication. https://doi.org/10.1111/bju.12363
- Peng B. (2025). Comment on Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials. Archives of endocrinology and metabolism, 69(6), e250516. https://doi.org/10.20945/2359-4292-2025-0516
